If you are ambidextrous, feel smug and ignore this.
Keep your keys, wallet, or whatever opens doors, in your weak-side pocket.
This is a bit counterintuitive. I used to keep them in my strong-side pocket for years. It’s natural to use your strong hand to unlock a door or buy a sandwich. But it causes problems when you need to open a door while carrying something awkward/heavy (say groceries, a cat, etc).
You should be carrying awkward things with your strong hand. It’s safer and easier. But when your strong-hand is full, it’s hard to get keys from your strong-side pocket. Meanwhile, keys in your weak-side pocket are still easy to employ.
I’m not especially dexterous, but in my experience, using my weak hand to unlock something hasn’t been a problem. I expected it to be harder, but honestly it hasn’t been perceptibly more difficult. Keeping keys in my weak-side pocket has been nothing but good.
Mobile-phones, pocketknives, cameras, PDAs, etc. should be in your strong-side pocket.
You should be using your strong-hand when you use them, but more importantly you (generally) don’t need to use them while carrying something. Cutting stuff while carrying a bag of groceries is a bad idea, for example.
But, anything you need to use while your strong hand is full should still live on your weak side with your keys. Phones make handy flashlights, for example.
Hold drinks with your weak hand.
I’ve been trying to train myself to do this for years, and I haven’t been able to.
The theory is that your weak hand is plenty up to the task of bringing a glass to your mouth (if it isn’t, you shouldn’t be drinking!), and it’s useful to have your strong hand free. Plus holding a cold drink makes your hand cold and wet, which surprisingly isn’t cool when you need to shake with that hand. So holding drinks in your left hand = a better first impression.